2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Base Information

Chemical Name:2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid
CAS No.:1344992-35-3
Molecular Formula:C₂₁H₁₅ClF₄N₂O₇
Molecular Weight:518.806
Hs Code.:

Synonyms:2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

There total 8 articles about 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344992-34-2
2-propen-1-yl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

: 1344992-35-3
2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Guidance literature:: With sodium 4-methylbenzenesulfinate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

Reference yield:

: 497866-29-2
3-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

: 1344992-35-3
2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

3: indium(III) chloride / 9 h / 75 - 82 °C

4: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

With indium(III) chloride; boron tribromide; potassium carbonate; sodium 4-methylbenzenesulfinate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 497866-09-8
3-(4-chloro-2-fluoro-5-((2-oxo-1,2-dihydropyridin-3-yl)oxy)phenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1344992-35-3
2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

2: indium(III) chloride / 9 h / 75 - 82 °C

3: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

With indium(III) chloride; potassium carbonate; sodium 4-methylbenzenesulfinate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;