4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

Base Information

Chemical Name:4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole
CAS No.:945006-75-7
Molecular Formula:C₁₄H₁₅BrN₂OS
Molecular Weight:339.256
Hs Code.:

Synonyms:4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

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Chemical Property of 4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

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Technology Process of 4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

There total 1 articles about 4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5-bromo-3-(4-methoxybenzyl)-2-methylsulfanylimidazole-4-carboxaldehyde

: 1779-49-3
Methyltriphenylphosphonium bromide

: 945006-75-7
4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

5-bromo-3-(4-methoxybenzyl)-2-methylsulfanylimidazole-4-carboxaldehyde; In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.1021/ol0602304

Reference yield: 97.0%

: 945006-75-7
4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

: 124-38-9,18923-20-1
carbon dioxide

: 945006-76-8
1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole-4-carboxylic acid

Guidance literature:: 4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/ol0602304

Reference yield:

: 945006-75-7
4-bromo-1-(4-methoxybenzyl)-2-methylsulfanyl-5-vinylimidazole

: 945006-79-1
2-[1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-yl]pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -78 °C

1.2: 97 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 80 percent / pyridine; triphenylphosphine; carbon tetrachloride / acetonitrile / 4 h / 80 °C

3.1: 81 percent / o-xylene / 1 h / 165 °C / microwave irradiation

4.1: 91 percent / (2-biphenyl)dicyclohexylphosphine; K₃PO₄ / Pd(dba)2 / dioxane / 0.67 h / 150 °C / microwave irradiation

5.1: 86 percent / NiCl₂*6H₂O; NaBH₄ / methanol; tetrahydrofuran / 0.17 h / -25 °C

With pyridine; tetrachloromethane; sodium tetrahydroborate; potassium phosphate; n-butyllithium; triphenylphosphine; nickel dichloride; CyJohnPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; o-xylene; acetonitrile; 4.1: Suzuki-Miyaura cross coupling;
DOI:10.1021/jo0707232