N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

Base Information

Chemical Name:N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide
CAS No.:1459809-11-0
Molecular Formula:C₂₅H₂₇N₅O₂S
Molecular Weight:461.588
Hs Code.:

Synonyms:N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

Chemical Property:

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Technology Process of N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

There total 15 articles about N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1459809-10-9
7,8-dihydroxy-N-(4-((4-nitrophenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo-[c]azepine-2(3H)-carbothioamide

: 1459809-11-0
N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

Guidance literature:: With sodium sulfide; In 1,4-dioxane; water; at 90 ℃; for 1h;
DOI:10.1002/anie.201302530

Reference yield:

: 94838-59-2
tert-butyl 4-aminophenethylcarbamate

: 1459809-11-0
N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

Guidance literature:: Multi-step reaction with 6 steps

1: Oxone / dichloromethane; ethanol; water / 12 h / 20 °C

2: acetic acid / dimethyl sulfoxide / 60 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

4: dichloromethane / 16 h / 20 °C

5: triethylamine / tetrahydrofuran / 16 h / 20 °C

6: sodium sulfide / 1,4-dioxane; water / 1 h / 90 °C

With hydrogenchloride; sodium sulfide; Oxone; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1002/anie.201302530

Reference yield:

: 1459809-00-7
tert-butyl 4-((4-nitrophenyl)diazenyl)phenethylcarbamate

: 1459809-11-0
N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

2: dichloromethane / 16 h / 20 °C

3: triethylamine / tetrahydrofuran / 16 h / 20 °C

4: sodium sulfide / 1,4-dioxane; water / 1 h / 90 °C

With hydrogenchloride; sodium sulfide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1002/anie.201302530