(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

Base Information

Chemical Name:(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide
CAS No.:1003890-41-2
Molecular Formula:C₂₈H₄₇O₇PSi
Molecular Weight:554.736
Hs Code.:

(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

Synonyms:(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

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Chemical Property of (1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

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Technology Process of (1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

There total 6 articles about (1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1003890-38-7
C₂₈H₄₅O₇PSi

: 1003890-41-2
(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

Guidance literature:: With 2-nitrobenzenesulfonyl hydrazide; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol7025944

Reference yield: 72.0%

: C₂₈H₄₅O₇PSi

: 1003890-41-2
(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

Guidance literature:: With 2-nitrobenzenesulfonyl hydrazide; triethylamine; In 1,2-dichloro-ethane; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo2003506

Reference yield:

: 887343-98-8
(4R,6R)-2-Allyloxy-4,6-divinyl-[1,3,2]dioxaphosphinane 2-oxide

: 1003890-33-2
C₂₂H₃₈O₃Si

: 1003890-41-2
(1R,6R,8S)-8-((3R,4S,5R)-6-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-3,5-dimethylhexyl)-2,9,10-trioxa-1-phosphabicyclo[4.3.1]dec-4-ene 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; p-benzoquinone / dichloromethane / 0.75 h / Reflux

1.2: 70 °C

2.1: 2-nitrobenzenesulfonyl hydrazide; triethylamine / dichloromethane; 1,2-dichloro-ethane / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2-nitrobenzenesulfonyl hydrazide; triethylamine; p-benzoquinone; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol301007h