1003890-33-2Relevant academic research and scientific papers
A multifaceted phosphate tether: Application to the C1-C14 subunit of dolabelides A-D
Waetzig, Joshua D.,Hanson, Paul R.
, p. 109 - 112 (2008/09/16)
A phosphate tether approach to the C1-14 subunit of dolabelide is described. The phosphate tether serves a multifaceted role mediating several processes, including (i) diastereotopic differentiation via RCM, (ii) selective CM by imparting Type III behavior to the exocyclic olefin, (iii) regioselective hydrogenation, and (iv) regioselective Pd(0)-catalyzed reductive opening of the bicyclic phosphate. Overall, this strategy uses orthogonal protecting- and leaving-group properties innate to phosphate esters to rapidly assembly the titled subunit.
