4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-

Base Information

Chemical Name:4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-
CAS No.:870194-63-1
Molecular Formula:C14H12 Cl N O5
Molecular Weight:309.706
Hs Code.:
Mol file:870194-63-1.mol

Synonyms:3-(2-Chloro-4-methoxycarbonylmethylphenyl)-5-methylisoxazole-4-carboxylicacid

Suppliers and Price of 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-

Chemical Property:

PSA：89.63000
LogP:2.71710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-

There total 10 articles about 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 870194-62-0
3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid tert-butyl ester

: 870194-63-1
3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2006.05.055

Reference yield:

: 496856-45-2
(3-chloro-4-cyanophenyl)acetic acid methyl ester

: 870194-63-1
3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 55 percent / HCO₂H / Raney-Ni / 10 h / 110 °C

2.1: 90 percent / NH₂OH*HCl; Na₂CO₃ / H₂O / 2 h / 20 °C

3.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C

4.1: KN(TMS)2; Et₃N / diethyl ether / 1 h / 20 °C

4.2: Et₃N / acetonitrile / 3 h / 0 °C

5.1: 100 percent / TFA / 4 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; triethylamine; trifluoroacetic acid; nickel; In diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.055

Reference yield:

: 496856-44-1
methyl 2-(3-chloro-4-(triuoromethylsulfonyloxy)phenyl)acetate

: 870194-63-1
3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / Pd(Ph₃P)4 / dimethylformamide / 30 h / 80 °C

2.1: 55 percent / HCO₂H / Raney-Ni / 10 h / 110 °C

3.1: 90 percent / NH₂OH*HCl; Na₂CO₃ / H₂O / 2 h / 20 °C

4.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C

5.1: KN(TMS)2; Et₃N / diethyl ether / 1 h / 20 °C

5.2: Et₃N / acetonitrile / 3 h / 0 °C

6.1: 100 percent / TFA / 4 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; triethylamine; trifluoroacetic acid; nickel; In diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.055