Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃

Base Information

• Chemical Name: Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃
• CAS No.: 149639-98-5
• Molecular Formula: C₃₀H₄₂N₄O₇
• Molecular Weight: 570.686
• Mol file: 149639-98-5.mol

Synonyms:Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃

Chemical Property of Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃

There total 1 articles about Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-O-benzyl-L-threonine (15260-10-3) + (2S,3R)-2-(2-Amino-acetylamino)-3-benzyloxy-N-methyl-butyramide; compound with trifluoro-acetic acid → Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH3 (149639-98-5)

Guidance literature:

With 2-methylmorpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 3h; Yield given; Ambient temperature;

DOI:10.1021/jo00066a026

Reference yield:

Boc-Thr(OBn)-Gly-Thr(OBn)-NHCH3 (149639-98-5) → [(4R,5S,11S,12R)-2-(4-Chloro-benzyloxy)-4,12-dimethyl-5-methylcarbamoyl-2,7,10-trioxo-1,3-dioxa-6,9-diaza-2λ5-phospha-cyclododec-11-yl]-carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / H₂ / 10percent Pd/C / methanol

2: 1) diisopropylethylamine, 2) 3-chloroperbenzoic acid / 1) CH₂Cl₂, CH₃CN, room temperature, 3 h, 2a) 0 deg C to room temperature, b) room temperature, 20 min

With hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jo00066a026

upstream raw materials:

N-Boc-O-benzyl-L-threonine