2-TRIFLUOROMETHYL-3-CYANOPYRIDINE

Base Information

• Chemical Name: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE
• CAS No.: 870066-15-2
• Molecular Formula: C₇H₃F₃N₂
• Molecular Weight: 172.109
• Hs Code.: 2933399090
• Mol file: 870066-15-2.mol

Synonyms:2-Trifluoromethylnicotinonitrile

Chemical Property of 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.215mmHg at 25°C
• Refractive Index: 1.4641
• Boiling Point: 208.3oC at 760 mmHg
• Flash Point: >110oC
• PSA: 36.68000
• Density: 1.344
• LogP: 1.97208
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Trifluoromethyl)nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE

There total 4 articles about 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienenitrile (1146961-23-0) → 2-(trifluoromethyl)pyridine-3-carbonitrile (870066-15-2)

Guidance literature:

With ammonia; In methanol; water; at 60 ℃; for 3.5h;

Reference yield: 65.0%

(4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienenitrile → 2-(trifluoromethyl)pyridine-3-carbonitrile (870066-15-2)

Guidance literature:

With ammonia; In methanol; water; at 60 ℃; for 3.5h;

DOI:10.1021/ol800458k

Reference yield:

zinc(II) cyanide (557-21-1) + 3-bromo-2-(trifluoromethyl)pyridine (590371-58-7) → 2-(trifluoromethyl)pyridine-3-carbonitrile (870066-15-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 1h; Microwave irradiation;

upstream raw materials:

5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienenitrile

2-(trifluoromethyl)nicotinamide

zinc(II) cyanide

3-bromo-2-(trifluoromethyl)pyridine

Downstream raw materials:

3-cyano-2-(trifluoromethyl)pyridine 1-oxide

N-(Trifluoracetyl)harnstoff

(2-(trifluoromethyl)pyridin-3-yl)methanamine

Refernces

• 1、 -. "1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS". Paragraph 0615-0616. . Retrieved 2019/07/10.
• 2、 -. "1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS". Page/Page column 121. . Retrieved 2018/09/25.