1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine

Base Information

• Chemical Name: 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine
• CAS No.: 1056162-06-1
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.1390896
• Mol file: 1056162-06-1.mol

Synonyms:1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine;2-(Trifluoromethyl)-3-pyridinemethanamine

Chemical Property of 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine

Chemical Property:

• Boiling Point: 194℃
• PKA: 7.42±0.29(Predicted)
• Flash Point: 71℃
• PSA: 38.91000
• Density: 1.293
• LogP: 2.25940
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

(2-(Trifluoromethyl)pyridin-3-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine

There total 3 articles about 1-[2-(Trifluoromethyl)pyridin-3-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trifluoromethyl)pyridine-3-carbonitrile (870066-15-2) → (2-(trifluoromethyl)pyridin-3-yl)methanamine (1056162-06-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In acetic acid; at 20 ℃; for 5h; under 760.051 Torr;

Reference yield:

2-(trifluoromethyl)nicotinamide (959108-47-5) → (2-(trifluoromethyl)pyridin-3-yl)methanamine (1056162-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / acetic acid / 5 h / 20 °C / 760.05 Torr

With hydrogen; triethylamine; trifluoroacetic anhydride; palladium 10% on activated carbon; In dichloromethane; acetic acid;

Reference yield:

3-bromo-2-(trifluoromethyl)pyridine (590371-58-7) → (2-(trifluoromethyl)pyridin-3-yl)methanamine (1056162-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C / Microwave irradiation

2: ammonium hydroxide / methanol / 2 h / 30 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; methanol;

upstream raw materials:

2-(trifluoromethyl)nicotinamide

2-(trifluoromethyl)pyridine-3-carbonitrile

3-bromo-2-(trifluoromethyl)pyridine

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