4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

Base Information

Chemical Name:4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester
CAS No.:1360620-64-9
Molecular Formula:C₁₁H₉F₃O₅
Molecular Weight:278.185
Hs Code.:

Synonyms:4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

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Chemical Property of 4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

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Technology Process of 4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

There total 8 articles about 4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285575-54-3
methyl 3-formyl-4-methoxy-5-trifluoromethyl benzoate

: 1360620-64-9
4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

Guidance literature:: With sodium chlorite; 2-methyl-but-2-ene; citric acid; In water; acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1360620-64-9
4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.75 h / -70 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran; hexane / 16 h / 60 °C

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: Amberlyst-15 / hexane / 3 h / Reflux

7.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

7.2: 1 h / 0 °C

7.3: 16 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1.5 h / 20 °C

9.1: sodium chlorite; 2-methyl-but-2-ene; citric acid / water; acetonitrile / 1 h / 20 °C

With hydrogenchloride; sodium chlorite; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; water; potassium carbonate; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; Amberlyst-15; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 336628-67-2
2-hydroxy-3-(trifluoromethyl)benzaldehyde

: 1360620-64-9
4-methoxy-5-trifluoromethylisophthalic acid-1-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: Amberlyst-15 / hexane / 3 h / Reflux

4.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

4.2: 1 h / 0 °C

4.3: 16 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1.5 h / 20 °C

6.1: sodium chlorite; 2-methyl-but-2-ene; citric acid / water; acetonitrile / 1 h / 20 °C

With sodium chlorite; N-Bromosuccinimide; 2-methyl-but-2-ene; potassium carbonate; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; Amberlyst-15; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetonitrile;