336628-67-2Relevant articles and documents
Roles of phenol groups and auxiliary ligand of copper(II) complexes with tetradentate ligands in the aerobic oxidation of benzyl alcohol
Zhan, Guangli,Zhong, Wei,Wei, Zhenhong,Liu, Zhenzhen,Liu, Xiaoming
, p. 8286 - 8297 (2017/07/10)
Herein, six copper(ii) complexes with multidentate ligands, [Cu(HL1)(OAc)(HOAc)] (1), [Cu(HL2)(OAc)] (2), [Cu(HL3)(OAc)] (3), [CuL4(OAc)] (4), [Cu(HL2)Cl] (5), and [Cu(HL3)Cl] (6) {H2L1 = [bis(3-tert-butyl-2-hydroxybenzyl)](2-pyridylmethyl)amine, H2L2 = [(3-tert-butyl-2-hydoxybenzyl)(3-trifluoromethyl-2-hydroxybenzyl) (2-pyridylmethyl)]amine, H2L3 = [bis(3-trifluoromethyl-2-hydroxybenzyl)] (2-pyridylmethyl)amine, and HL4 = [bis(2-pyridylmethyl)] (3-tert-butyl-2-hydroxybenzyl)amine}, are reported. The complexes were characterized by UV-vis spectroscopy, high-resolution mass spectrometry, X-ray single-crystal diffraction analysis and electrochemistry. These copper(ii) complexes have been investigated as catalysts for the aerobic oxidation of benzyl alcohol to benzaldehyde mediated by TEMPO (2,2,6,6-tetramethylpiperidinyl-1-oxyl) radical in water at ambient temperature. Mechanistic investigations have revealed that the phenolate/phenol is involved in the intramolecular proton transfer with a bound substrate in catalysis. Hence, the presence of the trifluoromethyl group on the phenol ring significantly affects the catalysis process since the substituent affects the acidity of phenol, and subsequently, the intramolecular proton transfer from the bound substrate. During catalysis, the dissociation of the auxiliary ligand (Cl- or OAc-) occurred in the SN1 pathway, and it is necessary for the substrate to bind. To complete the catalytic cycle, the cleaved auxiliary ligand rebinds to the metal center to regenerate the catalyst.
Synthesis of obscuraminol A using an organocatalyzed enantioselective Henry reaction
Filippova, Liudmila,Antonsen, Simen,Stenstr?m, Yngve,Hansen, Trond Vidar
supporting information, p. 6572 - 6577 (2016/09/23)
The first synthesis of the polyunsaturated amino alcohol natural product obscuraminol A is reported. This stereoselective synthesis was based on an anti- and enantioselective organocatalyzed Henry reaction followed by a chemoselective SmI2-mediated reduction that affected only the nitro-group of the Henry product. These efforts yielded obscuraminol A where the configuration of the all-Z skipped double bonds was conserved from the starting material, i.e. the ethyl ester of (all-Z)-eicosa-5,8,11,14,17-pentaenoic acid. Our synthesis confirmed the reported structure of obscuraminol A.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
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Paragraph 0001035, (2015/04/15)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
NOVEL PHENOL DERIVATIVE
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, (2012/07/28)
Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t
Highly enantioselective henry reactions in water catalyzed by a copper tertiary amine complex and applied in the synthesis of (S)-N-trans-feruloyl octopamine
Lai, Guoyin,Guo, Fengfeng,Zheng, Yueqin,Fang, Yang,Song, Haigang,Xu, Kun,Wang, Sujing,Zha, Zhenggen,Wang, Zhiyong
, p. 1114 - 1117 (2011/03/21)
It's in the water! A new copper tertiary amine complex was prepared and applied in asymmetric Henry reactions in water and in the short synthesis of (S)-N-trans-feruloyl octopamine. This catalytic system provided an approach to the enantioselective Henry reaction of aldehydes with hydroxyl substituents (see graphic).
CHEMICAL COMPOUNDS
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Page/Page column 28, (2008/12/04)
This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
TISSUE FACTOR PRODUCTION INHIBITOR
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Page/Page column 84, (2010/11/26)
A medicament which has an activity of inhibiting production of tissue factor and comprises an LXR ligand as an active ingredient; and a medicament for treatment and/or prophylaxis of vascular restenosis following angioplasty, endarterectomy, percutaneous transluminal coronary angioplasty (PTCA) or stent implantation, or treatment and/or prophylaxis of blood coagulation diseases, diseases induced by platelet aggregation including stable or unstable angina pectoris, cardiovascular and cerebrovascular diseases including thromboembolism formation diseases accompanying diabetes, rethrombosis following thrombolysis, cerebral ischemic attack, infarction, stroke, ischemia-derived dementia, peripheral artery disease, thromboembolism formation diseases during use of an aorta-coronary artery bypass, glomerulosclerosis, renal embolism, tumor or cancer metastasis, which comprises an LXR ligand as an active ingredient.
BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS
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Page/Page column 167-168, (2010/11/08)
Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, OH, alkoxy, optionally substituted amino or the like; R3 represents an H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno or the like; R4 and R5 respectively represent an H, optionally substituted alkyl, halogeno or the like; R6 and R7 respectively represent an H or alkyl; R8 represents a -X2R10 [wherein R10 represents a -COR11 (wherein R11 represents an OH, optionally substituted alkoxy, optionally substituted amino or the like), -SO2R12 (wherein R12 represents an optionally substituted alkyl, optionally substituted amino or the like), tetrazole-5-yl or the like; and X2 represents a single bond, optionally substituted alkylene or the like]; X1 represents an -NH-, -O-, -S- or the like; Y1 represents an optionally substituted phenyl or optionally substituted 5-membered or 6-membered aromatic heterocyclyl; and Y2 represents an optionally substituted aryl, substituted heterocyclyl or the like.]
Method for producing optically active salicylaldimine copper complex
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, (2008/06/13)
There is provided a method for producing an optically active salicylaldimine copper complex, which method is characterized in that an optically active amino alcohol compound represented by the following formula (1) is reacted with copper hydroxide (II) in an organic solvent. wherein R1 and R2 which are the same or different, each represent lower alkyl groups and the like which may be substituted, X1 and X2 which are the same or different, each represent a hydrogen atom, lower alkyl groups and the like, and the symbol * designates an asymmetric carbon atom.
The synthesis and use in asymmetric epoxidation of metal salen complexes derived from enantiopure trans-cyclopentane- and cyclobutane-1,2-diamine
Daly, Adrian M.,Gilheany, Declan G.
, p. 127 - 137 (2007/10/03)
A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidation of alkenes.
