2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine

Base Information

Chemical Name:2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine
CAS No.:134749-52-3
Molecular Formula:C₁₄H₂₁N₃
Molecular Weight:231.341
Hs Code.:
DSSTox Substance ID:DTXSID501215144
Nikkaji Number:J371.835B

Synonyms:2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine;134749-52-3;DTXSID501215144;Octahydro-2-(phenylmethyl)-2H-pyrazino[1,2-a]pyrazine;8-benzyl-1,2,3,4,5,6,7,8,9,9a-decahydro-pyrazino[1,2-a]pyrazine

Suppliers and Price of 2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:231.173547683
Heavy Atom Count:17
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2CCN(CC2CN1)CC3=CC=CC=C3

Technology Process of 2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine

There total 5 articles about 2-benzyloctahydro-2H-pyrazino[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 134749-51-2
2-benzyl-8-(trifluoromethylsulfonyl)octahydropyrazino<1,2-a>pyrazine-1,4-dione

: 134749-52-3
2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 18h; Heating;

Reference yield:

: 134749-45-4
ethyl 1-benzylpiperazine-2-carboxylate

: 134749-52-3
2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 1.) -75 deg C, 1 h, 2.) -> r.t.

2: 69 percent / H₂ / 10percent Pd-C / acetic acid / 1 h / 2068.6 Torr / Ambient temperature

3: 82 percent / NaHCO₃ / CH₂Cl₂ / 3 h / 0 °C

4: 57 percent / ethanol / 0.5 h / 0 °C

5: 56 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;

Reference yield:

: 134749-46-5
1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine

: 134749-52-3
2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / H₂ / 10percent Pd-C / acetic acid / 1 h / 2068.6 Torr / Ambient temperature

2: 82 percent / NaHCO₃ / CH₂Cl₂ / 3 h / 0 °C

3: 57 percent / ethanol / 0.5 h / 0 °C

4: 56 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;