1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine

Base Information

• Chemical Name: 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine
• CAS No.: 134749-46-5
• Molecular Formula: C₁₅H₁₉F₃N₂O₄S
• Molecular Weight: 380.388
• Mol file: 134749-46-5.mol

Synonyms:1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine

Chemical Property of 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine

There total 2 articles about 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

trifluoromethylsulfonic anhydride (358-23-6) + ethyl 1-benzylpiperazine-2-carboxylate (134749-45-4) → 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine (134749-46-5)

Guidance literature:

With triethylamine; In dichloromethane; 1.) -75 deg C, 1 h, 2.) -> r.t.;

Reference yield:

ethyl 1,4-dibenzylpiperazin-2-carboxylate (72351-59-8) → 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine (134749-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 1-chloroethyl carbonochloridate, 2.) MeOH / 1.) 1,2-dichloroethane, a) 0 deg C, 15 min., b) reflux, 1 h, 2.) reflux, 1 h

2: 94 percent / Et₃N / CH₂Cl₂ / 1.) -75 deg C, 1 h, 2.) -> r.t.

With methanol; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In dichloromethane;

Reference yield:

1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine (134749-46-5) → 2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine (134749-52-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / H₂ / 10percent Pd-C / acetic acid / 1 h / 2068.6 Torr / Ambient temperature

2: 82 percent / NaHCO₃ / CH₂Cl₂ / 3 h / 0 °C

3: 57 percent / ethanol / 0.5 h / 0 °C

4: 56 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;

upstream raw materials:

trifluoromethylsulfonic anhydride

ethyl 1-benzylpiperazine-2-carboxylate

ethyl 1,4-dibenzylpiperazin-2-carboxylate

Downstream raw materials:

octahydro-2H-pyrazino<1,2-a>pyrazin

2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine

2-benzyl-8-(trifluoromethylsulfonyl)octahydropyrazino<1,2-a>pyrazine-1,4-dione

2-methyloctahydro-2H-pyrazino[1,2-a]pyrazine