N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Base Information

• Chemical Name: N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
• CAS No.: 1629780-28-4
• Molecular Formula: C₂₈H₂₆N₂O₄S
• Molecular Weight: 486.591
• Mol file: 1629780-28-4.mol

Synonyms:N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Chemical Property of N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

There total 2 articles about N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-ethoxy-4-iodobenzene (699-08-1) + C19H15NO4S (1264630-54-7) → N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide (1629780-28-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1055/s-0033-1340902

Reference yield:

6-(N-tosylamino)coumarin (92856-41-2) → N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide (1629780-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetone / 6 h / Reflux

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1055/s-0033-1340902

Reference yield: 69.0%

N-[3-(4-ethoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide (1629780-28-4) → 9-(4-ethoxyphenyl)-4-methyl-7-tosyl-7,8-dihydro-4,7-phenanthrolin-3(4H)-one (1629780-41-1)

Guidance literature:

With iron(III) chloride; In acetonitrile; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0033-1340902

upstream raw materials:

6-(N-tosylamino)coumarin

1-ethoxy-4-iodobenzene

C₁₉H₁₅NO₄S

Downstream raw materials:

9-(4-ethoxyphenyl)-4-methyl-7-tosyl-7,8-dihydro-4,7-phenanthrolin-3(4H)-one