4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Base Information

Chemical Name:4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide
CAS No.:1289942-55-7
Molecular Formula:C₂₀H₁₈F₄N₄O₂
Molecular Weight:422.382
Hs Code.:

Synonyms:4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Suppliers and Price of 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide
1mg
$ 65.00

Total 4 raw suppliers

Chemical Property of 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide is an impurity of Enzalutamide (M199800), an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex.

Technology Process of 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

There total 7 articles about 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

: 749927-69-3
4-bromo-2-fluoro-N-methylbenzanamide

: 208122-09-2
2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

: 1289942-55-7
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Guidance literature:: With 2-acetylcyclohexanone; potassium carbonate; copper(l) chloride; In N,N-dimethyl-formamide; at 120 - 130 ℃; for 5.25h; Time; Reagent/catalyst; Inert atmosphere;

Reference yield: 36.0%

: 1289942-66-0
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1289942-55-7
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 749927-69-3
4-bromo-2-fluoro-N-methylbenzanamide

: 1289942-55-7
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C

1.2: 105 °C / Inert atmosphere

1.3: pH 4

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(l) chloride; In dichloromethane; water; N,N-dimethyl-formamide;