2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

Base Information

• Chemical Name: 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide
• CAS No.: 208122-09-2
• Molecular Formula: C₁₂H₁₂F₃N₃O
• Molecular Weight: 271.242
• Mol file: 208122-09-2.mol

Synonyms:2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

Chemical Property of 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

There total 6 articles about 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-[4-cyano-3-(tri-fluoromethyl)phenyl]-2-methyl-2-nitropropanamide → 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide (208122-09-2)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; isopropyl alcohol; at 90 ℃; for 1h;

DOI:10.1039/c4ra00332b

Reference yield: 51.0%

4-amino-2-trifluoromethylbenzonitrile (654-70-6) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid (94744-50-0) → 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide (208122-09-2)

Guidance literature:

4-amino-2-trifluoromethylbenzonitrile; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; With oxalyl dichloride;

With sodium hydrogencarbonate; In tetrahydrofuran;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

Boc-Aib-OH (30992-29-1) + 4-amino-2-trifluoromethylbenzonitrile (654-70-6) → 2-amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide (208122-09-2)

Guidance literature:

Boc-Aib-OH; 4-amino-2-trifluoromethylbenzonitrile; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 10 - 30 ℃; Inert atmosphere;

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 - 60 ℃; for 0.5h; Further stages;

upstream raw materials:

4-amino-2-trifluoromethylbenzonitrile

2-bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methylpropanamide

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

Boc-Aib-OH

Downstream raw materials:

4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid methyl ester

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide