tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate
CAS No.:869365-92-4
Molecular Formula:C18H16 Cl F2 N O3
Molecular Weight:367.78
Hs Code.:
Mol file:869365-92-4.mol

Synonyms:tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Suppliers and Price of tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-4-CHLORO-2-(2,6-DIFLUOROBENZOYL)PHENYLCARBAMATE 95.00%
5MG
$ 505.96

Total 2 raw suppliers

Chemical Property of tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Chemical Property:

PSA：60.44000
LogP:3.79740

Purity/Quality:: TERT-BUTYL-4-CHLORO-2-(2,6-DIFLUOROBENZOYL)PHENYLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

There total 1 articles about tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 18437-66-6
N-(t-butoxycarbonyl)-4-chloroaniline

: 18063-02-0
2,6-difluorobenzoylchloride

: 869365-92-4
tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate

Guidance literature:: N-(t-butoxycarbonyl)-4-chloroaniline; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -30 ℃; for 3.33333h; Inert atmosphere;

2,6-difluorobenzoylchloride; In tetrahydrofuran; pentane; at -78 ℃; for 0.833333h; Inert atmosphere;
DOI:10.1002/anie.201200994

Reference yield: 100.0%

: 869365-92-4
tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate

: 28910-83-0
(2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone

Guidance literature:: tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate; With trifluoroacetic acid; In dichloromethane; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 869365-92-4
tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate

: 869363-13-3
4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere

5.1: toluene / 4 h / 80 °C / Inert atmosphere

6.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; potassium carbonate; acetic acid; trifluoroacetic acid; sodium nitrite; In ethanol; dichloromethane; water; toluene; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1002/anie.201200994