tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate
• CAS No.: 869365-92-4
• Molecular Formula: C18H16 Cl F2 N O3
• Molecular Weight: 367.78
• Mol file: 869365-92-4.mol

Synonyms:tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Chemical Property of tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

Chemical Property:

• PSA: 60.44000
• LogP: 3.79740

Purity/Quality:

99% ^*data from raw suppliers

TERT-BUTYL-4-CHLORO-2-(2,6-DIFLUOROBENZOYL)PHENYLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate

There total 1 articles about tert-butyl 4-chloro-2-(2,6-difluorobenzoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-(t-butoxycarbonyl)-4-chloroaniline (18437-66-6) + 2,6-difluorobenzoylchloride (18063-02-0) → tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate (869365-92-4)

Guidance literature:

N-(t-butoxycarbonyl)-4-chloroaniline; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -30 ℃; for 3.33333h; Inert atmosphere;

2,6-difluorobenzoylchloride; In tetrahydrofuran; pentane; at -78 ℃; for 0.833333h; Inert atmosphere;

DOI:10.1002/anie.201200994

Reference yield: 100.0%

tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate (869365-92-4) → (2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone (28910-83-0)

Guidance literature:

tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate; With trifluoroacetic acid; In dichloromethane; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate (869365-92-4) → 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid (869363-13-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere

5.1: toluene / 4 h / 80 °C / Inert atmosphere

6.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; potassium carbonate; acetic acid; trifluoroacetic acid; sodium nitrite; In ethanol; dichloromethane; water; toluene; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;

DOI:10.1002/anie.201200994

upstream raw materials:

N-(t-butoxycarbonyl)-4-chloroaniline

2,6-difluorobenzoylchloride

Downstream raw materials:

(2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone

4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid

tert-butyl (3-(4-chloro-2-(2,6-difluorobenzoyl)phenyl)prop-2-yn-1-yl)carbamate

8-chloro-1-(2,6-difluorophenyl)-3,4-dihydrobenzo[c]azepin-5-one

Refernces