(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

Base Information

Chemical Name:(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide
CAS No.:545394-09-0
Molecular Formula:C₂₁H₂₂INO₃
Molecular Weight:463.315
Hs Code.:

Synonyms:(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

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Technology Process of (Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

There total 5 articles about (Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 545394-10-3
3-(4-tert-butylphenyl)-N-(2,3-dihydro[b][1,4]dioxin-6-yl)propiolamide

: 545394-09-0
(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

Guidance literature:: With acetic acid; sodium iodide; for 4h; Heating;
DOI:10.1021/jm049485i

Reference yield:

: 772-38-3
4-tert-Butylphenylacetylene

: 545394-09-0
(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 75 percent / tetrahydrofuran; hexane / -78 - 25 °C

2.1: 70 percent / aq. KOH / dioxane / 18 h / Heating

3.1: 53 percent / HOBt*H₂O; iPr₂NEt; EDCI*HCl / dimethylformamide / 18 h / 25 °C

4.1: 80 percent / NaI; AcOH / 4 h / Heating

With potassium hydroxide; n-butyllithium; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm049485i

Reference yield:

: 220006-53-1
3-(4-(tert-butyl)phenyl)propiolic acid

: 545394-09-0
(Z)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-iodoacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / HOBt*H₂O; iPr₂NEt; EDCI*HCl / dimethylformamide / 18 h / 25 °C

2: 80 percent / NaI; AcOH / 4 h / Heating

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049485i