Technology Process of N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide
There total 12 articles about N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
water; N,N-dimethyl-formamide;
at 130 ℃;
for 0.5h;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 2 h / 0 - 50 °C
2.1: hydrogenchloride / water / 3 h / Reflux
3.1: ammonium chloride; iron / ethanol / 3 h / Reflux
4.1: pyridine / dichloromethane / 5 h / 20 °C
5.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 72 h / 60 °C / Inert atmosphere
6.1: potassium carbonate; methanol / 5 h / 20 °C
7.1: triethylamine / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere
8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.5 h / 130 °C / microwave irradiation
With
pyridine; hydrogenchloride; methanol; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid; N-iodo-succinimide / 30 h / 20 °C
2: trichlorophosphate / 1 h / 90 °C
3: triethylamine / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere
4: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.5 h / 130 °C / microwave irradiation
With
N-iodo-succinimide; potassium carbonate; acetic acid; triethylamine; trichlorophosphate;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide;