124703-78-2

Usage

Uses

Used in Pharmaceutical Industry:
4(1H)-Pyrimidinone, 6-ethyl(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to be incorporated into diverse molecular structures, enhancing the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4(1H)-Pyrimidinone, 6-ethyl(9CI) is utilized as a building block in the creation of agrochemicals, contributing to the development of pesticides and other agricultural chemicals that aim to improve crop protection and yield.
Used in Materials Science:
4(1H)-Pyrimidinone, 6-ethyl(9CI) is employed in the field of materials science for its potential role in the production of polymers and other organic compounds, which can be used in the development of novel materials with specific properties for various applications.
Used in Research and Development:
4(1H)-Pyrimidinone, 6-ethyl(9CI) is also used as a research tool in the study of its biological activities, such as anti-inflammatory and antimicrobial properties, aiding in the advancement of medical and biological sciences by providing insights into potential therapeutic agents and mechanisms of action.

Upstream product

• 3473-63-0 formamidine acetic acid 
• 4949-44-4 ethyl propanoylacetate 
• 30414-53-0 methyl propanoyl acetate 
• 883528-73-2 3-amino-4-methyl crotonic acid methylester 
• 71-36-3 butan-1-ol 
• 53939-83-6 4-hydroxy-2-mercapto-6-ethylpyrimidine 
• 56-04-2 6-methyl-2-thiouracil 

Downstream Products

• 141602-25-7 4-chloro-6-ethylpyrimidine 
• 141602-29-1 4-chloro-5-iodo-6-ethylpyrimidine 
• 1392099-63-6 N-{5-[4-ethyl-6-(6-methyl-pyridin-3-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide 
• 1392099-64-7 N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide 
• 1391979-24-0 N-[5-(4-chloro-6-ethyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-2,4-difluoro-benzenesulfonamide 
• 1391979-30-8 N-[5-(4-chloro-6-ethyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-4-fluoro-benzenesulfonamide 
• 1392099-55-6 N-{5-[4-(3,4-dimethoxy-phenyl)-6-ethyl-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-56-7 N-{5-[4-(3-dimethylaminomethyl-phenyl)-6-ethyl-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-61-4 N-{5-[4-ethyl-6-(2-methoxy-3-trifluoromethyl-phenyl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-62-5 N-{5-[4-ethyl-6-(3-fluoro-4-methoxy-phenyl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 182369-73-9 2-(2,4-difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1823642-95-0 5-bromo-4-(1,1-difluoroethyl)pyrimidine 
• 1391978-22-5 N-{5-[4-(4-cyclopropylpiperazin-1-yl)-6-ethylpyrimidin-5-ylethynyl]-2-methylpyridin-3-yl}-4-fluorobenzenesulfonamide 
• 1391978-21-4 N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide 

Relevant academic research and scientific papers

Synthesis method of voriconazole impurity B

The invention relates to a synthesis method of a voriconazole impurity B. The synthesis method of the voriconazole impurity B comprises the steps of firstly, dissolving formamidine acetate and sodiumtert-butoxide in methyl alcohol, conducting stirring und

Drug intermediate and preparation method thereof

The invention provides a drug intermediate and a preparation method thereof. The method comprises a preparation method of a compound. The compound is [4-(1,1-difluoro-ethyl)-pyridine]-5-methylamine hydrochloride. The method comprises the following steps of using 4-(1,1-difluoro ethyl)-5-pyridine formaldehyde to take reduction reaction with sodium borohydride in water to obtain 4-(1,1-difluoro ethyl)-5-pyridine-methyl alcohol. A pyridine derivative M can be used for the development and screening of new medicine for treating various chronic diseases such as diabetes mellitus and alopecia. The synthesis method of the compound also has the advantages that the operation is simple; the efficiency is high; the raw material cost is low. The synthesis route has the advantages that the process is simple and convenient; the synthesis route is suitable for factory amplified production.

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

5-Alkynyl-pyridines

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification

NEW 5-ALKYNYL-PYRIDINES

5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of P13Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR

This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a pharmaceutically acceptable salt thereof.