C₂₁H₂₉ClFN₃O₄

Base Information

Chemical Name:C₂₁H₂₉ClFN₃O₄
CAS No.:1271811-45-0
Molecular Formula:C₂₁H₂₉ClFN₃O₄
Molecular Weight:441.93
Hs Code.:

C<sub>21</sub>H<sub>29</sub>ClFN<sub>3</sub>O<sub>4</sub>

Synonyms:C₂₁H₂₉ClFN₃O₄

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Chemical Property of C₂₁H₂₉ClFN₃O₄

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Technology Process of C₂₁H₂₉ClFN₃O₄

There total 7 articles about C₂₁H₂₉ClFN₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1271811-39-2
tert-butyl 6-(2-oxopiperidin-1-yl)-1,4-oxazepane-4-carboxylate

: 4863-91-6
3-chloro-5-fluoroaniline

: 1271811-45-0
C₂₁H₂₉ClFN₃O₄

Guidance literature:: tert-butyl 6-(2-oxopiperidin-1-yl)-1,4-oxazepane-4-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - -30 ℃; Inert atmosphere;

With benzenesulfonyl chloride; In tetrahydrofuran; at -78 - 10 ℃;

3-chloro-5-fluoroaniline; With sodium hydride; In tetrahydrofuran; mineral oil; for 1.5h; Reflux;

Reference yield:

: 748805-97-2
6-oxo-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

: 1271811-45-0
C₂₁H₂₉ClFN₃O₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C

2.1: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr

3.1: triethylamine / Cooling with ice

4.1: sodium hydride / tetrahydrofuran; mineral oil / 7 h / 65 °C / Cooling with ice

5.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / -78 - -30 °C / Inert atmosphere

5.2: -78 - 10 °C

5.3: 1.5 h / Reflux

With hydroxylamine hydrochloride; hydrogen bromide; hydrogen; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; water; mineral oil;

Reference yield:

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1271811-45-0
C₂₁H₂₉ClFN₃O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling with ice

1.2: 20 °C

2.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 18 h / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C

4.1: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr

5.1: triethylamine / Cooling with ice

6.1: sodium hydride / tetrahydrofuran; mineral oil / 7 h / 65 °C / Cooling with ice

7.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / -78 - -30 °C / Inert atmosphere

7.2: -78 - 10 °C

7.3: 1.5 h / Reflux

With sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; ethylbenzene; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;