Technology Process of (2R)-methyl tropinate
There total 10 articles about (2R)-methyl tropinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl methyl ether; Methyl phenyldiazoacetate;
[(1-dodecylsulfonyl-pyrrolidin-2-yl)methanediyldioxy]4Rh2;
In
hexane;
at 20 ℃;
for 1.5h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1002/adsc.200303089
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi, 2.) CuCN, 3.) BF3*Et2O
2: 96 percent / Et3N, DMAP / CH2Cl2 / 12 h / Ambient temperature
3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, RT, 8 h
4: CrO3, aq. H2SO4 / acetone / 0.25 h / 0 °C
5: 95 percent / diethyl ether / 0.17 h
6: 93 percent / K2CO3 / methanol / 0.17 h / 0 °C
With
chromium(VI) oxide; dmap; n-butyllithium; dimethylsulfide; sulfuric acid; boron trifluoride diethyl etherate; potassium carbonate; ozone; triethylamine;
In
methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1016/S0957-4166(97)00063-3
