(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Base Information

Chemical Name:(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide
CAS No.:1372620-78-4
Molecular Formula:C₄₂H₅₉NO₂Si
Molecular Weight:638.021
Hs Code.:

Synonyms:(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Suppliers and Price of (S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Chemical Property:

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Technology Process of (S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

There total 8 articles about (S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1372620-76-2
(S)-10-(tert-butyldiphenylsilyloxy)octadeca-6,11-dienoic acid

: 64-04-0
phenethylamine

: 1372620-78-4
(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 24h;
DOI:10.3762/bjoc.7.158

Reference yield:

: 1191-25-9
6-Hydroxyhexanoic acid

: 1372620-78-4
(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / dichloromethane / 5 h / 40 °C

2.1: acetonitrile / 12 h / Inert atmosphere; Reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h

With dmap; phosphorus tribromide; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 3.1: Wittig reaction / 3.2: Wittig reaction;
DOI:10.3762/bjoc.7.158

Reference yield:

: 1372620-74-0
C₂₈H₄₀O₂Si

: 1372620-78-4
(S)-10-(tert-butyldiphenylsilyloxy)-N-phenethyloctadeca-6,11-dienamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h

With dmap; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1.1: Wittig reaction / 1.2: Wittig reaction;
DOI:10.3762/bjoc.7.158