(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

Base Information

Chemical Name:(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester
CAS No.:642087-18-1
Molecular Formula:C₄₅H₆₃ClN₂O₁₀
Molecular Weight:827.456
Hs Code.:

(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

Synonyms:(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

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Chemical Property of (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

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Technology Process of (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

There total 11 articles about (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37755-48-9,40298-04-2
benzyl (2S)-2-hydroxy-4-methylpentanoate

: 642087-18-1
(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / EDCI; DMAP / CH₂Cl₂ / 17 h / 23 °C

2: 100 percent / H₂ / Pd/C / ethyl acetate / 1.5 h / 23 °C

3: Et₃N / tetrahydrofuran / 3.5 h / 23 °C

4: 229 mg / Et₃N; DMAP / toluene / 0.5 h / 23 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo035077v

Reference yield:

: 180181-02-6
3-(tert-Butoxycarbonyl)amino-2,2-dimethylpropanoic Acid

: 642087-18-1
(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / EDCI; DMAP / CH₂Cl₂ / 17 h / 23 °C

2: 100 percent / H₂ / Pd/C / ethyl acetate / 1.5 h / 23 °C

3: Et₃N / tetrahydrofuran / 3.5 h / 23 °C

4: 229 mg / Et₃N; DMAP / toluene / 0.5 h / 23 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo035077v

Reference yield:

: 642087-20-5
2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid benzyl ester

: 642087-18-1
(2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate / 1.5 h / 23 °C

2: Et₃N / tetrahydrofuran / 3.5 h / 23 °C

3: 229 mg / Et₃N; DMAP / toluene / 0.5 h / 23 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jo035077v