N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide
CAS No.:871231-10-6
Molecular Formula:C₂₅H₂₅FN₆OS
Molecular Weight:476.578
Hs Code.:

Synonyms:N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

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Technology Process of N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

There total 3 articles about N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₉FN₄O₂S

: 50541-93-0
4-amino-1-benzylpiperidine

: 871231-10-6
N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: C₁₃H₉FN₄O₂S; With 4-methyl-morpholine; isobutyl chloroformate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.25h;

4-amino-1-benzylpiperidine; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 871231-31-1
methyl 2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxylate

: 871231-10-6
N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 4 h / Heating / reflux

2: 4-methyl-morpholine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.25 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 5604-46-6
2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

: 871231-10-6
N-(1-benzylpiperidin-4-yl)-2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Heating / reflux

2: hydrogenchloride / methanol; water / 0.75 h / 140 °C / Micriwave vessel

3: lithium hydroxide / tetrahydrofuran; methanol / 4 h / Heating / reflux

4: 4-methyl-morpholine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.25 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; potassium carbonate; isobutyl chloroformate; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); water; acetonitrile;