ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate

Base Information

• Chemical Name: ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate
• CAS No.: 514797-24-1
• Molecular Formula: C₁₇H₂₆O₃Si
• Molecular Weight: 306.477
• Mol file: 514797-24-1.mol

Synonyms:ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate

Chemical Property of ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate

There total 2 articles about ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-ethyl 2-hydroxycinnamate (3943-94-0,17041-46-2,6236-62-0) + tert-butyldimethylsilyl chloride (18162-48-6) → ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate (514797-24-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1081/SCC-120014986

Reference yield: 30.0%

ethyl acrylate (140-88-5,9003-32-1) + 2-propene-tert-butyldimethylsilyloxybenzene → ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate (514797-24-1)

Guidance literature:

With Cl₂Ru=CHPh(PCy₃)[bis(1,3-Mes-2-ylimidazolidine)]; In dichloromethane; for 12h; Heating;

DOI:10.1021/ja0214882

Reference yield: 95.0%

ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate (514797-24-1) → (E)-3-(2-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-ol (514797-25-2)

Guidance literature:

ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 - 20 ℃; for 5h;

With hydrogenchloride; In water;

DOI:10.1021/ja5019749

upstream raw materials:

(E)-ethyl 2-hydroxycinnamate

tert-butyldimethylsilyl chloride

ethyl acrylate

Downstream raw materials:

(E)-3-(2-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-ol

2-phenylchromene

(E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enal

acetic acid (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-enol ester