(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Name:(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:185518-25-6
Molecular Formula:C₃₂H₅₂N₂O₆Si
Molecular Weight:588.86
Hs Code.:

(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

Synonyms:(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

There total 2 articles about (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185515-75-7
(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoic acid benzyl ester

: 185518-25-6
(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 2 h / 760 Torr / Ambient temperature

2: 1-hydroxybenzotriazole, N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide, N,N-diisopropylethylamine / tetrahydrofuran / 1.) -5 deg C, 3 h, 2.) room temperature, 16 h

With N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jo961932h

Reference yield:

: (S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoic acid

: Leu-Pro-OBzl trifluoroacetate

: 185518-25-6
(S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With N-<(1H-benzotriazol-1-yl)(dimethylamino)methylene>-N-methylmethanaminium hexafluorophosphate N-oxide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Yield given; 1.) -5 deg C, 3 h, 2.) room temperature, 16 h;
DOI:10.1021/jo961932h