(6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Base Information

• Chemical Name: (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone
• CAS No.: 649724-99-2
• Molecular Formula: C₃₃H₃₅NO₄
• Molecular Weight: 509.645
• Mol file: 649724-99-2.mol

Synonyms:(6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Chemical Property of (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

There total 1 articles about (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2-methoxybenzyl)zinc(II) chloride (312693-15-5) + trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester (648905-79-7) → (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (649724-99-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tetra-(n-butyl)ammonium iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 2h; Heating / reflux;

Reference yield:

(6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (649724-99-2) → [6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2004.07.072

Reference yield:

(6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (649724-99-2) → 12-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-7,12-dihydro-benzo[a]anthracene-3,8-diol

Guidance literature:

Multi-step reaction with 2 steps

1: LAH / tetrahydrofuran / 20 °C

2: BBr₃ / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; boron tribromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2004.07.072

upstream raw materials:

(2-methoxybenzyl)zinc(II) chloride

trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester