Chlorozinc(1+);1-methanidyl-2-methoxybenzene

Base Information

• Chemical Name: Chlorozinc(1+);1-methanidyl-2-methoxybenzene
• CAS No.: 312693-15-5
• Molecular Formula: C8H9 Cl O Zn
• Molecular Weight: 222.002
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID10391496
• Mol file: 312693-15-5.mol

Synonyms:chlorozinc(1+);1-methanidyl-2-methoxybenzene;DTXSID10391496;J-018338

Chemical Property of Chlorozinc(1+);1-methanidyl-2-methoxybenzene

Chemical Property:

• Vapor Pressure: 1.9mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 9.23000
• Density: g/cm³
• LogP: 2.69790
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 219.963334
• Heavy Atom Count: 11
• Complexity: 82.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxybenzylzinc chloride solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xi,C
• Statements: 11-19-36/37-40-37-34-14
• Safety Statements: 16-29-33-45-36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC=C1[CH2-].Cl[Zn+]
• Uses: 2-Methoxybenzylzinc chloride can be used as:An intermediate in the preparation of 2,4-diamino-6-arylmethylquinazolines as possible DHFR inhibitors.A model organozinc compound in the Pd-catalyzed synthesis of α-aryl tertiary amides by reacting with carbamoyl chlorides.A substrate in the synthesis of forensically significant pyridine and pyrimidine derivatives.

Technology Process of Chlorozinc(1+);1-methanidyl-2-methoxybenzene

There total 1 articles about Chlorozinc(1+);1-methanidyl-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-Methoxybenzyl chloride (7035-02-1) + zinc(II) chloride (7646-85-7,24359-56-6) → (2-methoxybenzyl)zinc(II) chloride (312693-15-5)

Guidance literature:

With magnesium; lithium chloride; In tetrahydrofuran; ligand, Mg, LiCl, and ZnCl2 (1:2.5:1.25:1.1 molar ratio) for 1 h at 25°C;

DOI:10.1039/b812396a

Reference yield: 95.0%

(2-methoxybenzyl)zinc(II) chloride (312693-15-5) → 1,2-bis(2-methoxyphenyl)ethane (14310-34-0)

Guidance literature:

With Desyl chloride; dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); In tetrahydrofuran; at 60 ℃;

DOI:10.1021/ol0258536

Reference yield: 87.0%

(2-methoxybenzyl)zinc(II) chloride (312693-15-5) + trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester (648905-79-7) → (6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (649724-99-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tetra-(n-butyl)ammonium iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 2h; Heating / reflux;

upstream raw materials:

o-Methoxybenzyl chloride

zinc(II) chloride

Downstream raw materials:

1,2-bis(2-methoxyphenyl)ethane

(6-methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(2-methoxybenzyl)pyridin-3-yl)cyclopropanecarboxamide

2-[6-(2-methoxybenzyl)pyridin-2-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinazoline