17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

Base Information

Chemical Name:17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan
CAS No.:133042-78-1
Molecular Formula:C₂₆H₂₇NO₃
Molecular Weight:401.505
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

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Technology Process of 17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

There total 4 articles about 17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 133042-79-2
17-(cyclopropylmethyl)-4,5α-epoxy-6-phenyl-3,6,14β-trihydroxymorphinan

: 133042-78-1
17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

Guidance literature:: With hydrogenchloride; for 0.333333h;
DOI:10.1021/jm00109a027

Reference yield:

: 16590-41-3
Naltrexone

: 133042-78-1
17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / diethyl ether; cyclohexane; tetrahydrofuran / 16 h / Ambient temperature

2: 88 percent / conc. HCl / 0.33 h

With hydrogenchloride; In tetrahydrofuran; diethyl ether; cyclohexane;
DOI:10.1021/jm00109a027

Reference yield:

: 591-51-5
phenyllithium

: 133042-78-1
17-(cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6-phenylmorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / diethyl ether; cyclohexane; tetrahydrofuran / 16 h / Ambient temperature

2: 88 percent / conc. HCl / 0.33 h

With hydrogenchloride; In tetrahydrofuran; diethyl ether; cyclohexane;
DOI:10.1021/jm00109a027