(R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester

Base Information

• Chemical Name: (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester
• CAS No.: 73908-45-9
• Molecular Formula: C₂₄H₂₈N₂O₆S
• Molecular Weight: 472.562
• Mol file: 73908-45-9.mol

Synonyms:(R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester

Chemical Property of (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester

There total 4 articles about (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetyl-L-cysteine benzylester (73908-42-6) → 2-acetylamino-acrylic acid benzyl ester (73908-43-7) + 2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester (73908-44-8) + (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester (73908-45-9)

Guidance literature:

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; copper(l) chloride; In dichloromethane; at 20 ℃; for 12h; Yield given;

DOI:10.1021/jo01303a043

Reference yield:

N-acetyl-L-cysteine benzylester (73908-42-6) → 2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester (73908-44-8) + (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester (73908-45-9)

Guidance literature:

With diisopropyl-carbodiimide; In acetonitrile; at 20 ℃; for 5h; Yield given. Title compound not separated from byproducts;

DOI:10.1021/jo01303a043

Reference yield:

O-benzyl-N,N'-diisopropylisourea (2978-10-1) → (R)-2-Acetylamino-3-(2-acetylamino-2-benzyloxycarbonyl-ethylsulfanyl)-propionic acid benzyl ester (73908-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent

2: 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 12 h / 20 °C

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In dichloromethane;

DOI:10.1021/jo01303a043

upstream raw materials:

N-acetyl-L-cysteine benzylester

O-benzyl-N,N'-diisopropylisourea

N-acetyl-l-cysteine