8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

Base Information

Chemical Name:8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One
CAS No.:330827-16-2
Molecular Formula:C₁₇H₁₃N₃O₃S
Molecular Weight:339.375
Hs Code.:

Synonyms:8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

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Chemical Property of 8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

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Technology Process of 8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

There total 7 articles about 8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 98-59-9
p-toluenesulfonyl chloride

: 330826-94-3
8,9-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-one

: 330827-16-2
8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(00)01916-X

Reference yield:

: 271-63-6
7-Azaindole

: 330827-16-2
8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: 44 percent / t-BuLi / tetrahydrofuran / -78 - 20 °C

2.1: 87 percent / HCl / benzene; CHCl₃ / Heating

3.1: 100 percent / NH₂NH₂*H₂O / ethanol / Heating

4.1: 76 percent / diisopropyl ethylamine / CH₂Cl₂ / 20 °C

5.1: 100 percent / aq. HCl / CH₂Cl₂

6.1: 95 percent / MsCl; TEA / CH₂Cl₂ / 0 °C

7.1: 40 percent / NaH / dimethylformamide / 20 °C

With hydrogenchloride; n-butyllithium; TEA; sodium hydride; hydrazine hydrate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)01916-X

Reference yield:

: 330827-14-0
6,7,8,9-tetrahydro-6-hydroxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-one

: 330827-16-2
8,9-Dihydro-8-(4-Methylphenylsulfonyl)Pyrido[3',2':4,5]Pyrrolo[1,2-c]Pyrimidin-9-One

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / MsCl; TEA / CH₂Cl₂ / 0 °C

2: 40 percent / NaH / dimethylformamide / 20 °C

With TEA; sodium hydride; methanesulfonyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)01916-X