5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

Base Information

Chemical Name:5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine
CAS No.:1401349-71-0
Molecular Formula:C₂₅H₂₁IN₄O₃S₂
Molecular Weight:616.503
Hs Code.:

Synonyms:5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

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Chemical Property of 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

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Technology Process of 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

There total 4 articles about 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

: 1401349-70-9
5-(3-iodo-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

: 98-59-9
p-toluenesulfonyl chloride

: 1401349-71-0
5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

Guidance literature:: 5-(3-iodo-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

p-toluenesulfonyl chloride; In mineral iol; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 269410-24-4
5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1401349-71-0
5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 85 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 12 h / 110 °C

3.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

4.2: 2 h / 20 °C

With iodine; sodium hydride; potassium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1401349-68-5
3-chloro-5-(1H-indol-5-yl)-1,2,4-thiadiazole

: 1401349-71-0
5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 12 h / 110 °C

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

3.2: 2 h / 20 °C

With iodine; sodium hydride; potassium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;