6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

Base Information

Chemical Name:6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester
CAS No.:107697-40-5
Molecular Formula:C₂₂H₂₆O₃S
Molecular Weight:370.513
Hs Code.:

Synonyms:6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

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Chemical Property of 6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

There total 7 articles about 6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 107697-39-2
6-Hydroxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

: 100-44-7
benzyl chloride

: 107697-40-5
6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1016/S0040-4039(00)84650-X

Reference yield:

: 617-54-9
citraconic acid dimethyl ester

: 107697-40-5
6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 28 percent / HC(OMe)3, conc. H₂SO₄ / methanol / Heating

2: 87 percent / 1N NaOH / 1 h / 60 °C

3: 78 percent / conc. H₂SO₄ / 1 h / 25 °C

4: 89 percent / PTSA / 16 h / Heating

5: 64 percent / Zn/Hg amalgam, HCl, H₂O / toluene / 6 h / Heating

6: 96 percent / K₂CO₃ / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; water; potassium carbonate; mercury; zinc; sulfuric acid; toluene-4-sulfonic acid; trimethyl orthoformate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)84650-X

Reference yield:

: 85460-73-7
2,3,5-trimethyl-4-hydroxy-benzenethiol

: 107697-40-5
6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 28 percent / HC(OMe)3, conc. H₂SO₄ / methanol / Heating

2: 87 percent / 1N NaOH / 1 h / 60 °C

3: 78 percent / conc. H₂SO₄ / 1 h / 25 °C

4: 89 percent / PTSA / 16 h / Heating

5: 64 percent / Zn/Hg amalgam, HCl, H₂O / toluene / 6 h / Heating

6: 96 percent / K₂CO₃ / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; water; potassium carbonate; mercury; zinc; sulfuric acid; toluene-4-sulfonic acid; trimethyl orthoformate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)84650-X