N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

Base Information

Chemical Name:N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine
CAS No.:1453185-67-5
Molecular Formula:C₃₆H₄₁N₅O₁₃
Molecular Weight:751.747
Hs Code.:

Synonyms:N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

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Chemical Property of N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

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Technology Process of N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

There total 5 articles about N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 111-90-0
ethoxyethoxyethanol

: 1453185-65-3
N-isobutyroyl-5’-carboxy-2’,3’-di-O-(carbobenzyloxy)guanosine

: 1453185-67-5
N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

Guidance literature:: N-isobutyroyl-5’-carboxy-2’,3’-di-O-(carbobenzyloxy)guanosine; With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

ethoxyethoxyethanol; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 12h;
DOI:10.1016/j.bmcl.2013.07.030

Reference yield:

: 81246-83-5
9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 1453185-67-5
N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 72 h / 20 °C

2.1: trichloroacetic acid / dichloromethane / 0.25 h / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / acetone; acetonitrile; water; diethyl ether / 25 °C

4.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h / 60 °C

With dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trichloroacetic acid; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2013.07.030

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1453185-67-5
N-isobutyroyl-5’-(diethyleneglycol monoethyl ether)-2’,3’-di-O-(carbobenzyloxy)guanosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 72 h / 20 °C

2.1: trichloroacetic acid / dichloromethane / 0.25 h / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / acetone; acetonitrile; water; diethyl ether / 25 °C

4.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h / 60 °C

With dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trichloroacetic acid; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2013.07.030