3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

Base Information

Chemical Name:3-(2',4',6'-tri-tert-butylphenyl)propiolic acid
CAS No.:31039-84-6
Molecular Formula:C₂₁H₃₀O₂
Molecular Weight:314.468
Hs Code.:

Synonyms:3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

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Chemical Property of 3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

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Technology Process of 3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

There total 9 articles about 3-(2',4',6'-tri-tert-butylphenyl)propiolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1618100-32-5
diethyl 1-(2',4',6'-tri-tert-butylphenyl)vinyl phosphate

: 31039-85-7
1-(2',4',6'-tri-tert-butylphenyl)acetylene

: 31039-84-6
3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

Guidance literature:: diethyl 1-(2',4',6'-tri-tert-butylphenyl)vinyl phosphate; With tert.-butyl lithium; In tert-butyl methyl ether; pentane; at -70 ℃; for 1h; Inert atmosphere;

carbon dioxide; In tert-butyl methyl ether; pentane; Inert atmosphere;
DOI:10.1016/j.tet.2014.05.002

Reference yield: 64.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1618100-32-5
diethyl 1-(2',4',6'-tri-tert-butylphenyl)vinyl phosphate

: 31039-84-6
3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

Guidance literature:: diethyl 1-(2',4',6'-tri-tert-butylphenyl)vinyl phosphate; With tert.-butyl lithium; In tert-butyl methyl ether; pentane; at -70 ℃; for 1h; Schlenk technique; Inert atmosphere;

carbon dioxide; With sodium hydroxide; In tert-butyl methyl ether; water; pentane;
DOI:10.1016/j.tet.2014.05.002

Reference yield:

: 3975-77-7
1-bromo-2,4,6-tri-tert-butylbenzene

: 31039-84-6
3-(2',4',6'-tri-tert-butylphenyl)propiolic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (i) nBuLi, (ii) I₂

2: CuCl, aq. NH₄OH

3: KOH

With potassium hydroxide; ammonium hydroxide; copper(l) chloride;
DOI:10.1021/ja00725a021