Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Base Information

Chemical Name:Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate
CAS No.:866393-54-6
Molecular Formula:C19H19 N O4
Molecular Weight:325.36
Hs Code.:
DSSTox Substance ID:DTXSID00468025
Nikkaji Number:J2.236.923G
Mol file:866393-54-6.mol

Synonyms:866393-54-6;Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate;Methyl 6-hydroxy-5-oxo-7-(1-phenylprop-2-enyl)-2,3-dihydro-1H-indolizine-8-carboxylate;DTXSID00468025;AKOS015911761;FT-0654336;A841751;Methyl 6-hydroxy-5-oxo-7-(1-phenylprop-2-en-1-yl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Suppliers and Price of Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL 6-HYDROXY-5-OXO-7-(1-PHENYLALLYL)-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYLATE 95.00%
5G
$ 909.56

Total 3 raw suppliers

Chemical Property of Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.626
Boiling Point:527.237°C at 760 mmHg
Flash Point:272.664°C
PSA：68.53000
Density:1.295g/cm³
LogP:2.60460
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:325.13140809
Heavy Atom Count:24
Complexity:625

Purity/Quality:

97% ^*data from raw suppliers

METHYL 6-HYDROXY-5-OXO-7-(1-PHENYLALLYL)-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C2CCCN2C(=O)C(=C1C(C=C)C3=CC=CC=C3)O

Technology Process of Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

There total 2 articles about Methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185198-40-7
1-(2-benzenesulfonyl-2-diazoacetyl)pyrrolidin-2-one

: 866393-54-6
methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Rh(II)

2: 95 percent / K₂CO₃ / acetone / 18 h / Heating

3: 80 percent / dimethylformamide / 1 h / Heating

With potassium carbonate; rhodium⁽²⁺⁾; In N,N-dimethyl-formamide; acetone; 2: Williamson etherification / 3: Claisen rearrangement;
DOI:10.1021/jo0511492

Reference yield:

: 185198-42-9
6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid methyl ester

: 866393-54-6
methyl 6-hydroxy-5-oxo-7-(1-phenylallyl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / acetone / 18 h / Heating

2: 80 percent / dimethylformamide / 1 h / Heating

With potassium carbonate; In N,N-dimethyl-formamide; acetone; 1: Williamson etherification / 2: Claisen rearrangement;
DOI:10.1021/jo0511492