Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate

Base Information

Chemical Name:Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate
CAS No.:866393-51-3
Molecular Formula:C₁₃H₁₅NO₄
Molecular Weight:249.266
Hs Code.:
DSSTox Substance ID:DTXSID50470739
Nikkaji Number:J2.236.921K
Wikidata:Q82298902
Mol file:866393-51-3.mol

Synonyms:866393-51-3;Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate;Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate;DTXSID50470739;Methyl7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate;Methyl 6-hydroxy-5-oxo-7-(prop-2-en-1-yl)-1,2,3,5-tetrahydroindolizine-8-carboxylate

Suppliers and Price of Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-7-ALLYL-6-HYDROXY-5-OXO-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYATE 95.00%
5MG
$ 505.77

Total 4 raw suppliers

Chemical Property of Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.586
Boiling Point:439.702°C at 760 mmHg
Flash Point:219.724°C
PSA：68.53000
Density:1.302g/cm³
LogP:1.01520
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:249.10010796
Heavy Atom Count:18
Complexity:487

Purity/Quality:

97% ^*data from raw suppliers

METHYL-7-ALLYL-6-HYDROXY-5-OXO-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C2CCCN2C(=O)C(=C1CC=C)O

Technology Process of Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate

There total 3 articles about Methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxyate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 866393-47-7
methyl 6-allyloxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

: 866393-51-3
methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; for 1h; Heating;
DOI:10.1021/jo0511492

Reference yield:

: 185198-40-7
1-(2-benzenesulfonyl-2-diazoacetyl)pyrrolidin-2-one

: 866393-51-3
methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Rh(II)

2: 96 percent / K₂CO₃ / acetone / 18 h / Heating

3: 70 percent / dimethylformamide / 1 h / Heating

With potassium carbonate; rhodium⁽²⁺⁾; In N,N-dimethyl-formamide; acetone; 2: Williamson etherification / 3: Claisen rearrangement;
DOI:10.1021/jo0511492

Reference yield:

: 185198-42-9
6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid methyl ester

: 866393-51-3
methyl 7-allyl-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / K₂CO₃ / acetone / 18 h / Heating

2: 70 percent / dimethylformamide / 1 h / Heating

With potassium carbonate; In N,N-dimethyl-formamide; acetone; 1: Williamson etherification / 2: Claisen rearrangement;
DOI:10.1021/jo0511492