(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1360616-48-3
Molecular Formula:C₃₈H₅₀N₂O₅Si
Molecular Weight:642.911
Hs Code.:

Synonyms:(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

There total 3 articles about (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1360616-46-1
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-hydroxyphenethyl)carbamoyl)pyrrolidine-1-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1360616-48-3
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 34h; Inert atmosphere;
DOI:10.1021/ja209924v

Reference yield:

: 51-67-2
tyrosamine

: 1360616-48-3
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: 1H-imidazole / dichloromethane / 34 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja209924v

Reference yield:

: 268729-12-0
(2S,4R)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

: 1360616-48-3
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((4-((tertbutyldimethylsilyl)oxy)phenethyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: 1H-imidazole / dichloromethane / 34 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja209924v