bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

Base Information

Chemical Name:bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine
CAS No.:815608-51-6
Molecular Formula:C₂₇H₃₀F₂N₄O₂
Molecular Weight:480.558
Hs Code.:

Synonyms:bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

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Chemical Property of bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

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Technology Process of bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

There total 1 articles about bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 212832-16-1
4-fluoro-N-(4-fluorophenyl)-N-[3-(piperazin-1-yl)propyl]aniline

: 815608-51-6
bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm049670w

Reference yield:

: 815608-51-6
bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

: 815608-54-9
3-[4-(4-aminophenylethyl)-1-piperazinyl]propyl-N,N-bis(4-fluorophenyl)amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; under 2068.59 Torr;
DOI:10.1021/jm049670w

Reference yield:

: 815608-51-6
bis-(4-fluoro-phenyl)-(3-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propyl)-amine

: 3-[4-(4-isothiocyanatophenylethyl)-1-piperazinyl]propyl-N,N-bis(4-fluorophenyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1: 820 mg / H₂ / Pd/C / methanol; ethyl acetate / 2068.59 Torr

2: 55 percent / aq. NaHCO₃ / CHCl₃ / 0 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; chloroform; ethyl acetate;
DOI:10.1021/jm049670w