5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol

Base Information

• Chemical Name: 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol
• CAS No.: 1006364-60-8
• Molecular Formula: C₂₄H₃₄O₅Si
• Molecular Weight: 430.616
• Mol file: 1006364-60-8.mol

Synonyms:5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol

Chemical Property of 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol

There total 5 articles about 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxose → 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol (1006364-60-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/ol7025558

Reference yield:

2,3-O-isopropylidene-L-lyxono-1,4-lactone (152006-17-2) → 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol (1006364-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1002/chem.201300741

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol (1006364-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1002/chem.201300741

upstream raw materials:

tert-butylchlorodiphenylsilane

2,3-O-isopropylidene-L-lyxono-1,4-lactone

2,3-O-isopropylidene-D-ribonic-γ-lactone

(3R,4R,5R)-4,5-dihydro-3,4-(O,O)-isopropylidene-5-mesyloxymethyl-2-(3H)-furanone

Downstream raw materials:

5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1,4-di-O-methanesulfonyl-L-lyxitol

C₂₄H₃₂O₄SeSi

acetic acid 6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl ester

7-[6-(tert-butyl-diphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl]-6-chloro-7H-purin-2-ylamine