ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

Base Information

Chemical Name:ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate
CAS No.:72482-24-7
Molecular Formula:C₁₇H₁₃ClFNO₃S
Molecular Weight:365.813
Hs Code.:

Synonyms:ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

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Chemical Property of ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

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Technology Process of ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

There total 11 articles about ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 105-36-2
ethyl bromoacetate

: 72482-23-6
7-chloro-3-(2-fluorophenyl)-6-mercapto-1,2-benzisoxazole

: 72482-24-7
ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 1h;
DOI:10.1021/jm00343a008

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 72482-24-7
ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

Guidance literature:: Multi-step reaction with 9 steps

1: 67 percent / AlCl₃ / 1,2-dichloro-ethane / 1.) from 5 deg C to RT, 30 min, 2.) reflux, 30 min

2: 76 percent / hydroxylamine hydrochloride, pyridine / 24 h / Heating

3: 98 percent / 1 h / Heating

4: 84 percent / sodium hydride / dimethylformamide / 0.67 h / 30 °C

5: 91 percent / pyridine hydrochloride / 2 h / 180 °C

6: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h

7: 80 percent / 0.75 h / 205 °C

8: 75 percent / 15percent aq. NaOH / methanol / 3 h / Heating

9: 77 percent / K₂CO₃ / dimethylformamide / 1 h / 65 °C

With pyridine; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; pyridine hydrochloride; sodium hydride; potassium carbonate; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008

Reference yield:

: 72482-06-5
7-Chloro-6-hydroxy-3-(2-fluorophenyl)-1,2-benzisoxazole

: 72482-24-7
ethyl <<7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl>thio>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride (50percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) 60 deg C, 2.5 h

2: 80 percent / 0.75 h / 205 °C

3: 75 percent / 15percent aq. NaOH / methanol / 3 h / Heating

4: 77 percent / K₂CO₃ / dimethylformamide / 1 h / 65 °C

With sodium hydroxide; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00343a008