4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Base Information

• Chemical Name: 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
• CAS No.: 342603-71-8
• Molecular Formula: C₂₇H₃₂IN₃O₅
• Molecular Weight: 605.473

Synonyms:4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property of 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 8 articles about 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 1-allyl ester 2-benzyl ester (342600-21-9) → 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (342603-71-8)

Guidance literature:

4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 1-allyl ester 2-benzyl ester; With Thiosalicylic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

3-chloro-3-methylbut-1-yne (1111-97-3) → 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (342603-71-8)

Guidance literature:

Multi-step reaction with 4 steps

1: CuCl; Cu⁽⁰⁾; Et₃N

2: Cu₂O; pyridine / 115 °C

3: Pd₂(dba)3; DPPB; thiosalicylic acid / tetrahydrofuran

4: DMAP / CH₂Cl₂

With pyridine; copper(I) oxide; dmap; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; thiosalicilyc acid; copper; triethylamine; 1,4-di(diphenylphosphino)-butane; copper(l) chloride; In tetrahydrofuran; dichloromethane; 2: Castro-Stevens reaction;

DOI:10.1016/S0960-894X(02)00425-0

Reference yield:

4-hydroxy-3,5-diiodopyridine (7153-08-4) → 4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (342603-71-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Cu₂O; pyridine / 115 °C

2: Pd₂(dba)3; DPPB; thiosalicylic acid / tetrahydrofuran

3: DMAP / CH₂Cl₂

With pyridine; copper(I) oxide; dmap; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; thiosalicilyc acid; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; dichloromethane; 1: Castro-Stevens reaction;

DOI:10.1016/S0960-894X(02)00425-0

upstream raw materials:

di-tert-butyl dicarbonate

4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid benzyl ester

4-hydroxy-3,5-diiodopyridine

3-chloro-3-methylbut-1-yne

Downstream raw materials:

(S)-1-[(2S,4R)-4-Benzyl-5-((3aS,9bS)-2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-pentyl]-4-(1-furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-piperazine-2-carboxylic acid (2,2,3,3,3-pentafluoro-propyl)-amide

(S)-1-[(2S,4R)-4-Benzyl-5-((3aS,9bS)-2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-pentyl]-4-(1-furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-piperazine-2-carboxylic acid (3,3,3-trifluoro-propyl)-amide

(S)-1-[(2S,4R)-4-Benzyl-5-((3aS,9bS)-2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-pentyl]-4-(1-furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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