(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

Base Information

Chemical Name:(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one
CAS No.:911319-63-6
Molecular Formula:C₃₃H₃₈N₂O₄Si
Molecular Weight:554.761
Hs Code.:

Synonyms:(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

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Chemical Property of (3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

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Technology Process of (3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

There total 8 articles about (3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911319-43-2
(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 911319-63-6
(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h; atmospheric pressure;
DOI:10.1021/ol061524s

Reference yield:

: 911319-41-0
benzyl (2S,3R)-(+)-6-tert-butyldimethylsilyloxy-2,3-diphenyl-4-morpholin-5-enecarboxylate

: 911319-63-6
(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetra-butylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2: 99 percent / DMAP / CH₂Cl₂; tetrahydrofuran / 12 h / Heating

3: H₂ / Pd/C / ethyl acetate / 12 h / 20 °C / atmospheric pressure

With dmap; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol061524s

Reference yield:

: 911319-42-1
(3R,5R,6S)-3-[(R)-Hydroxy-(6-methoxy-quinolin-4-yl)-methyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 911319-63-6
(3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / DMAP / CH₂Cl₂; tetrahydrofuran / 12 h / Heating

2: H₂ / Pd/C / ethyl acetate / 12 h / 20 °C / atmospheric pressure

With dmap; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol061524s