N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

Base Information

Chemical Name:N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide
CAS No.:1446235-99-9
Molecular Formula:C₃₁H₂₉F₂N₃O₈S₃
Molecular Weight:705.781
Hs Code.:

Synonyms:N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

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Chemical Property of N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

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Technology Process of N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

There total 12 articles about N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1446235-98-8
4-[5-amino-2-(2,4-difluorophenoxy)phenyl]-6-methyl-1-tosyl-1,6-dihydro-7H-pyrrolo[2,3-c] pyridin-7-one

: 594-44-5
Ethanesulfonyl chloride

: 1446235-99-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 2-bromo-1-(2,4-difluorophenoxy)-4-nitrobenzene

: 1446235-99-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / water; 1,4-dioxane / 16 h / 60 °C / Inert atmosphere

3: dichloromethane / 2 h / 0 - 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 701-45-1
2-bromo-1-fluoro-4-nitrobenzene

: 1446235-99-9
N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)-N-(ethylsulfonyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / dimethyl sulfoxide / 1 h / 110 °C

2: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / 100 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / water; 1,4-dioxane / 16 h / 60 °C / Inert atmosphere

4: dichloromethane / 2 h / 0 - 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;