N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Base Information

Chemical Name:N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide
CAS No.:157325-00-3
Molecular Formula:C₃₉H₄₇N₃O₃S
Molecular Weight:637.886
Hs Code.:

Synonyms:N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Suppliers and Price of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

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Technology Process of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

There total 4 articles about N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 62-53-3
aniline

: 150115-35-8
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

: 157325-00-3
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jm00020a010

Reference yield:

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 157325-00-3
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / 3A molecular sieves, NaCNBH₃ / ethanol / Ambient temperature

2: 76 percent / diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphonic chloride / CH₂Cl₂ / 20 h / Ambient temperature

With 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00020a010

Reference yield:

: 149910-63-4
N-α-(tert-butoxycarbonyl)-S-(triphenylmethyl)-L-cysteinal

: 157325-00-3
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / 3A molecular sieves, NaCNBH₃ / ethanol / Ambient temperature

2: 76 percent / diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphonic chloride / CH₂Cl₂ / 20 h / Ambient temperature

With 3 A molecular sieve; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00020a010