tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Base Information

Chemical Name:tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate
CAS No.:89371-81-3
Molecular Formula:C₂₉H₄₅N₃O₆
Molecular Weight:531.693
Hs Code.:

Synonyms:tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

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Chemical Property of tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

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Technology Process of tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

There total 9 articles about tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.4%

: 195828-75-2
tert.-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2-oxo-imidazolidine-4-carboxylate

: 117560-23-3
benzyl (2S)-2-aminodecanoate

: 89371-81-3
tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

: 89397-13-7
tert.-butyl (4S)-1-methyl-3-{(2R)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 48h; Ambient temperature;
DOI:10.1021/jm00122a003

Reference yield:

: benzyl (2S)-2-amino-n-decanoate

: 195828-75-2
tert.-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2-oxo-imidazolidine-4-carboxylate

: 89371-81-3
tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

: 89397-13-7
tert.-butyl (4S)-1-methyl-3-{(2R)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide;

Reference yield:

: 77999-24-7
(S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester

: 89371-81-3
tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 89.8 percent / K₂CO₃ / acetone / 72 h / Ambient temperature

2: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

3: 1) KOtBu / 1) THF, -50 deg C, 20 min, 2) -30 deg C, 1 h

4: 14 percent / K₂CO₃ / hexamethylphosphoric acid triamide / 48 h / Ambient temperature

With potassium tert-butylate; hydrogen; potassium carbonate; palladium; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1021/jm00122a003