C₂₀H₁₇F₄N₅O₃

Base Information

Chemical Name:C₂₀H₁₇F₄N₅O₃
CAS No.:1428986-22-4
Molecular Formula:C₂₀H₁₇F₄N₅O₃
Molecular Weight:451.38
Hs Code.:

C<sub>20</sub>H<sub>17</sub>F<sub>4</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:C₂₀H₁₇F₄N₅O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₀H₁₇F₄N₅O₃

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Technology Process of C₂₀H₁₇F₄N₅O₃

There total 8 articles about C₂₀H₁₇F₄N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1428986-21-3
butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

: 1428986-22-4
C₂₀H₁₇F₄N₅O₃

Guidance literature:: With water; potassium hydroxide; In isopropyl alcohol; at 55 ℃; for 6h;
DOI:10.1021/op300365e

Reference yield:

: 1428986-19-9
1-(tetrahydro-2H-pyran-4-yl)-2-trifluoromethyl-1H-imidazole

: 1428986-22-4
C₂₀H₁₇F₄N₅O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-hexyllithium / tetrahydrofuran / 0.58 h / -25 - -15 °C / Inert atmosphere

1.2: 1.5 h / -25 - -15 °C

2.1: copper diacetate; oxygen; triethylamine / acetonitrile

3.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 60 °C / Inert atmosphere

4.1: potassium hydroxide; water / isopropyl alcohol / 6 h / 55 °C

With water; oxygen; copper diacetate; n-hexyllithium; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; potassium hydroxide; In tetrahydrofuran; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300365e

Reference yield:

: 1005498-91-8
tetrahydro-2H-pyran-4-amine acetate

: 1428986-22-4
C₂₀H₁₇F₄N₅O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / toluene / 25 °C

2.1: triethylamine / toluene / 8 h / 50 °C

3.1: toluene / 25 °C

4.1: sulfuric acid / tetrahydrofuran / 5 h / 20 - 25 °C

5.1: n-hexyllithium / tetrahydrofuran / 0.58 h / -25 - -15 °C / Inert atmosphere

5.2: 1.5 h / -25 - -15 °C

6.1: copper diacetate; oxygen; triethylamine / acetonitrile

7.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 60 °C / Inert atmosphere

8.1: potassium hydroxide; water / isopropyl alcohol / 6 h / 55 °C

With sulfuric acid; water; oxygen; copper diacetate; n-hexyllithium; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; potassium hydroxide; In tetrahydrofuran; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/op300365e