(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

Base Information

Chemical Name:(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid
CAS No.:1334872-28-4
Molecular Formula:C₂₉H₂₆N₂O₅
Molecular Weight:482.536
Hs Code.:

Synonyms:(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

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Chemical Property of (S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

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Technology Process of (S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

There total 20 articles about (S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1334871-98-5
(S)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoate

: 1334872-28-4
(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

Guidance literature:: (S)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoate; With lithium hydroxide monohydrate; In ethanol; water; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=4;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 501031-61-4
2-(5-methyl-2-phenyloxazol-4-yl)acetaldehyde

: 1334872-28-4
(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

1.2: 0.17 h / -10 °C

2.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

3.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

3.2: pH 3

4.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane

5.2: 0.5 h / -78 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 4 h / -78 °C

7.1: ethylmagnesium bromide / diethyl ether / 0.17 h / -10 °C

8.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 12 h / 0 - 20 °C

9.1: lithium hydroxide monohydrate / ethanol; water / 2 h / 20 °C

9.2: pH 4

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; di-isopropyl azodicarboxylate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; toluene; 1.2: Horner-Wadsworth-Emmons olefination / 6.2: Davis asymmetric oxidation / 8.1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 1262547-46-5
(S)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

: 1334872-28-4
(S)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 12 h / 0 - 20 °C

2.1: lithium hydroxide monohydrate / ethanol; water / 2 h / 20 °C

2.2: pH 4

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; triphenylphosphine; In ethanol; water; toluene; 1.1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.05.028