4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Base Information

Chemical Name:4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)
CAS No.:1075707-16-2
Molecular Formula:C₃₀H₂₄N₄S₂
Molecular Weight:504.679
Hs Code.:

Synonyms:4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Suppliers and Price of 4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

There total 5 articles about 4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 943543-04-2
5-methyl-2-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazolee

: 221534-29-8
4,5-diiodo-1-methyl-2-phenyl-1H-imidazole

: 1075707-16-2
4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Guidance literature:: With palladium diacetate; cesium fluoride; DavePhos; In 1,4-dioxane; N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja802986y

Reference yield:

: 210490-49-6
4-bromo-5-methyl-2-phenylthiazoline

: 1075707-16-2
4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran / -78 - 20 °C

2: 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; diisopropylamine / ethanol / Reflux

3: ammonium acetate; acetic acid / Reflux

4: N,N-dimethyl-formamide / 20 °C

With n-butyllithium; ammonium acetate; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; acetic acid; diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jpca.7b00296

Reference yield:

: C₁₁H₉NOS

: 1075707-16-2
4,4'-(1-methyl-2-phenyl-1H-imidazole-4,5-diyl)bis(5-methyl-2-phenylthiazole)

Guidance literature:: Multi-step reaction with 3 steps

1: 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; diisopropylamine / ethanol / Reflux

2: ammonium acetate; acetic acid / Reflux

3: N,N-dimethyl-formamide / 20 °C

With ammonium acetate; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; acetic acid; diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jpca.7b00296